Lai A | yveskth

Alan Lai

PhD 2012 Biochemical Sciences, National Taiwan University, Taiwan; Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program, Academia Sinica, Taiwan.

MSc 2002 Microbiology with Distinction, University of Otago, New Zealand.

BSc 1999 Microbiology, University of Otago, New Zealand.

Publications

1. Chen WY, Wu YH, Tsai TH, Li RF, Lai AC, Li LC, Yang JL, Chang YJ. Group 2 innate lymphoid cells contribute to IL-33-mediated alleviation of cardiac fibrosis. Theranostics. 2021 Jan 1;11(6):2594.

2. Hsu TS, Lin YL, Wang YA, Mo ST, Chi PY, Lai AC, Pan HY, Chang YJ, Lai MZ. HIF-2α is indispensable for regulatory T cell function. Nat Commun. 2020 Oct 6;11(1):5005.

3. Lai YT, Chao HW, Lai AC, Lin SH, Chang YJ, Huang YS. CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis. J Biomed Sci. 2020 Apr 15;27(1):52

4. Wu YH, Lai AC, Chi PY, Thio CL, Chen WY, Tsai CH, Lee YL, Lukacs NW, Chang YJ. Pulmonary IL-33 orchestrates innate immune cells to mediate respiratory syncytial virus-evoked airway hyperreactivity and eosinophilia. Allergy. 2020 Apr;75(4):818-830.

5. *Chan YT, *Lai AC, Lin RJ, Wang YH, Wang YT, Chang WW, Wu HY, Lin YJ, Chang WY, Wu JC, Yu JC, Chen YJ, Yu AL. GPER-induced signaling is essential for the survival of breast cancer stem cells. Int J Cancer. 2020 Mar 15;146(6):1674-1685. (*Co-first author)

6. Lai AC, Chi PY, Thio CL, Han YC, Kao HN, Hsieh HW, Gervay-Hague J, Chang YJ. α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding. Front Chem. 2019 Nov 28;7:811.

7. Thio CL, Lai AC, Chi PY, Webster G, Chang YJ. Toll-like receptor 9-dependent interferon production prevents group 2 innate lymphoid cell-driven airway hyperreactivity. J Allergy Clin Immunol. 2019 Sep;144(3):682-697.e9.

8. Thio CL, Chi PY, Lai AC, Chang YJ. Regulation of type 2 innate lymphoid cell-dependent airway hyperreactivity by butyrate. J Allergy Clin Immunol. 2018 Dec;142(6):1867-1883.e12.

9. Lai YT, Su CK, Jiang ST, Chang YJ, Lai AC, Huang YS. Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction. J Neurosci. 2016 Dec 14;36(50):12661-12676.

10. Chang YJ, Hsuan YC, Lai AC, Han YC, Hou DR. Synthesis of α-C-Galactosylceramide via Diastereoselective Aziridination: The New Immunostimulant 4'-epi-C-Glycoside of KRN7000. Org Lett.2016 Feb 19;18(4):808-11.

11. Ho KC, Chiang YJ, Lai AC, Liao NS, Chang YJ, Yang-Yen HF, Yen JJ. CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling. Cell Death Dis. 2014 Nov 13;5(11):e1518.

12. Chang WW, Lin RJ, Yu J, Chang WY, Fu CH, Lai A, Yu JC, Yu AL. The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors. Breast Cancer Res. 2013 May 12;15(3):R39.

13. Lai AC, Tsai CF, Hsu CC, Sun YN, Chen YJ. Complementary Fe(3+)- and Ti(4+)-immobilized metal ion affinity chromatography for purification of acidic and basic phosphopeptides. Rapid Commun Mass Spectrom. 2012;26(18):2186‐2194.

12. Chou PH, Chen SH, Liao HK, Lin PC, Her GR, Lai AC, Chen JH, Lin CC, Chen YJ. Nanoprobe-based affinity mass spectrometry for selected protein profiling in human plasma. Anal Chem. 2005 Sep 15;77(18):5990-7.

13. Lai AC, Tran S, Simmonds RS. Functional characterization of domains found within a lytic enzyme produced by Streptococcus equi subsp. zooepidemicus. FEMS Microbiol Lett. 2002 Sep 24;215(1):133-8.