COLLEGE OF PHARMACY, TAIPEI MEDICAL UNIVERSITY, TAIWAN
AND
DEPARTMENT OF CHEMISTRY, SCHOOL OF ENGINEERING SCIENCES IN CHEMISTRY, BIOTECHNOLOGY AND HEALTH (CBH)
KTH ROYAL INSTITUTE OF TECHNOLOGY, SWEDEN
RECENT PUBLICATIONS
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Manuscripts In Preparation
49
Kao MR, Karmakar Saldivar R, Hsieh YSY*, Production of therapeutic glycoproteins in glycoengineered plant: old farm for new crops, Current Opinion in Biotechnology, 2024, Accept for publication
48
Kao MR, Parker J, Oehme D, Chang SC, Cheng LC, Wang D, Srivastava V, Wagner J, Harris PJ, Hsieh YSY*, Substrate specificities of variants of barley (1,3)- and (1,3;1,4)-β-D-glucanases resulting from mutagenesis and segment hybridization, Biochemistry, 2024, 63 (9), 1194–1205
47
Hsieh YSY*, Kao MR, Tucker MR*, The knowns and unknowns of callose biosynthesis in terrestrial plants, Carbohydrate Research, 2024, 538, 109103
46
Chen TY, Shyur E, Ma TH, Wijeyewickrema L, Lin SW, Kao MR, Liang PH, Shie JJ, Chuang EY, Liou JP, Hsieh YSY*, Effect of sulfotyrosine and negatively charged amino acid of leech-derived peptides on binding and inhibitory activity against thrombin, ChemBioChem, 2024, 25, e202300744
45
Liu DW, Hsu SJ, Hsieh YSY, Liu HK, Lee CK, Polymethoxyflavone from Citrus depressa as an inhibitor against various variants of SARS-CoV-2 spike protein, Journal of Ethnopharmacology, 2024, 117412
44
Hsiung SY, Deng SX, Li J, Huang SY, Liaw CK, Haung SY, Wang CC, Hsieh YSY*, Machine learning-based monosaccharide profiling for tissue-specific classification of Wolfiporia extensa samples, Carbohydrate Polymers, 2023, 121338
43
Chang SC, Kao MR, Karmakar Saldivar R, Díaz-Moreno SM, Xing X, Furlanetto V, Yayo J, Divne C, Vilaplana F, Abbott AW, Hsieh YSY*, The Gram-positive bacterium Romboutsia ilealis harbors a polysaccharide synthase that can produce (1,3;1,4)-β-D-glucans, Nature Communications, 2023, 14, 4526
42
Dan M, Zheng Y, Zhao G, Hsieh YSY* & Wang, D*, Current insights of factors interfering the stability of lytic polysaccharide monooxygenases, Biotechnology Advances, 2023, 67, 108216
41
Chen YT, Liu CH, Pan WY, Jheng PR, Hsieh YSY, Burnouf T, Fan YJ, Chiang CC, Chen TY, Chuang, EY, Biomimetic platelet nanomotors for site-specific thrombolysis and ischemic injury alleviation, ACS Applied Materials & Interfaces, 2023, 115 (27), 32967–32983
40
Chiu PF, Lin I, Lu YL, Chang CN, Yu CH, Lin TS, Tsai KC, Hsieh YSY, Chen MJ, Lin MH, Liang PH, Design, structure–activity relationships, and enzyme kinetic studies of tricyclic and tetracyclic coumarin-based sulfamates as steroid sulfatase inhibitors, Bioorganic Chemistry, 2023, 138, 106581
39
Hyun GH, Jeong DH, Yang YY, Cho IH, Ha YJ, Xing X, Abbott DW, Hsieh YSY, Kang YP, Cha JH, Hong SS, Lee SJ, Kim YS, Kwon SW, Multivalent carbohydrate nanocomposites for tumor microenvironment remodeling to enhance anti-tumor immunity, ACS Nano, 2023, 17, 11567−11582
38
Zhou Y, Liao KS, Chen TY, Hsieh YSY, Wong CH, Effective organotin-mediated regioselective functionalization of unprotected carbohydrates, Journal of Organic Chemistry, 2023, 88, 11, 7174-7151
37
Hsiung SY, Li J, Imre B, Kao MR, Liao HC, Wang D, Chen CH, Liang PH, Harris PJ, Hsieh YSY*,
Structures of the xyloglucans in the monocotyledon family Araceae (aroids), Planta, 2023, 257, 39
36
Chang CN, Lin IC, Lin T, Chiu PF, Lu YL, Narwane M, Liu IC, Hng Y, Tsai KC, Lin MH, Hsieh YSY, Chen MJ, Liang PH. Design, Structure–Activity, and Kinetic Studies of 3-Benzyl-5-oxa-1,2,3,4-Tetrahydro-2H-chromeno-(3,4-c)pyridin-8-yl Sulfamates as Steroid Sulfatase Inhibitors. Bioorganic Chemistry, 2022, 106148
34
Li J, Hsiung SY, Kao M, Xing X, Chang SC, Wang D, Hsieh PY, Liang PH, Zhu Z, Cheng TJR, Shie JJ, Liou JP, Abbott SW, Kwon SW, Hsieh YSY*, Structural compositions and biological activities of cell wall polysaccharides in the rhizome, stem, and leaf of Polygonatum odoratum (Mill.) Druce, Carbohydrate Research. 2022, 521, 108662
33
Wang D*, Kao MR, Li J, Sun P, Meng Q, Vyas A, Liang PH, Wang YS, Hsieh YSY*, A novel two-step process in cellulose depolymerization: hematite-mediated photocatalysis by lytic polysaccharide monooxygenase and Fenton reaction, Journal of Agricultural and Food Chemistry. 2022, 70 (32), 9941–9947
32
Zheng Y, Li Y, Yang Y, Zhang Y, Wang D, Wang P, Wong ACY, Hsieh YSY*, Wang D* Recent advances in bioutilization of marine macroalgae carbohydrates: Degradation, metabolism, and fermentation, Journal of Agricultural and Food Chemistry. 2022, 70 (5), 1438–1453
31
Li Y, Zheng Y, Zhang Y, Yang Y, Wang P, Imre B, Wong ACY, Hsieh YSY*, Wang D* Brown algae carbohydrates: Structures, pharmaceutical properties, and research challenges, Marine Drugs. 2021, 19, 620
30
Wang D*, Lo Y, Zheng Y, Hsieh, YSY* Recent advances in screening methods for the functional investigation of lytic polysaccharide monooxygenases, Frontiers in Chemistry. 2021, 9, 119
29
Li J, Wang D, Chang SC, Liang PH, Shie J, Srivastava V, Guu SY, Khoo KH, Bulone V, Hsieh, YSY* Production of structurally defined chito-oligosaccharides with single N-acetylation pattern using a unique chitinase from Paenibacillus paculi, Journal of Agricultural and Food Chemistry. 2021, 69 (11), 3371–3379
28
Chang SC, Karmakar Saldivar R, Liang PH, Hsieh, YSY* Structures, biosynthesis, and physiological functions mixed-linkage glucans (MLGs), Cells. 2021, 10 (3), 510
27
Marcotuli I, Colasuonno P, Hsieh YSY, Fincher GB, Gadaleta A, Non-starch polysaccharides in durum wheat: a review, International Journal of Molecular Sciences. 2020, 21, 2933
26
Kim HM, Song Y, Hyun GH, Long NP, Park JH, Hsieh YSY, Kwon SW, Structural characterization and antioxidant activity determination of neutral and acidic polysaccharides from Panax ginseng C. A. Meyer, Molecules. 2020, 25, 791
25
Juang YP, Lin YY, Chan SH, Chang CK, Shie JJ, Hsieh YSY, Guh JH, Liang PH, Synthesis, distribution analysis and mechanism studies of N-acyl glucosamine-bearing oleanolic saponins, Bioorganic Chemistry. 2020, 99, 103835
24
Lin TS, Hsieh CH, Kuo C, Juang YP, Hsieh YSY, Chiang H, Hung SC, Jiang CC, Liang PH, Sulfation pattern of chondroitin sulfate in human osteoarthritis cartilages reveals a lower level of chondroitin-4-sulfate, Carbohydrate Polymers. 2020, 229, 115496
Pham T, Schwerdt JG, Shirley NJ, Xing X, Hsieh YSY, Srivastava V, Bulone V, Little A. Analysis of cell wall synthesis and metabolism during early germination of Blumeria graminis f. sp. hordei conidial cells induced in vitro. The Cell Surface, 2019, 100030
23.
22.
Li J, Wang D, Xing X, Cheng TJR, Liang PH, Bulone V, Park JH, Hsieh YSY*. Structural analysis and biological activity of cell wall polysaccharides extracted from Panax ginseng marc. International Journal of Biological Macromolecules, 2019, 135, 29-37
21.
Hsieh YSY*, Harris PJ. Xylans of red and green algae: what is known about their structures and how they are synthesised? Polymers, 2019, 11, 354
20.
Wang D, Li J, Wong CY, Aachmann F, Hsieh YSY*. A colorimetric assay to rapidly determine the activities of lytic polysaccharide monooxygenases. Biotechnology for Biofuels, 2018, 11, 215
19.
Roberts AW, Lahnstein J, Hsieh YSY, Xing X, Yap K, Chaves AM, Scavuzzo-Duggan TR, G Dimitroff G, Lonsdale A, Roberts EM, Bulone V, Fincher GB, Doblin MS, Bacic A, Burton RA. Functional characterization of a glycosyltransferase from the moss Physcomitrella patens involved in the biosynthesis of a novel cell wall arabinoglucan. The Plant Cell, 2018, 30 (6), 1293-1308
18.
Wang D, Li J, Salazar-Alvarez G, McKee LS, Srivastava V, Sellberg J, Bulone V, Hsieh YSY*. Production of functionalised chitins assisted by fungal lytic polysaccharide monooxygenase. Green Chemistry, 2018, 20, 2091-2100
Wang D, Aarstad O, Li J, McKee L, Sætrom G, Vyas A, Srivastava V, Aachmann F, Bulone V, Hsieh YSY*. Preparation of 4-deoxy-L-erythro-5-hexoseulose uronic acid (DEH) and guluronic acid-rich alginate using a unique exo-alginate lyase from Thalassotalea crassostreae, Journal of Agricultural and Food Chemistry, 2018, 66, 1435-1443
17.
16
Xing X, Hsieh YSY, Yap K, Ang ME, Lahnstein J, Tucker MR, Burton RA, Bulone V. Isolation and structural elucidation by 2D NMR of planteose, a major oligosaccharide in the mucilage of chia (Salvia hispanica L.) seed. Carbohydrate Polymers. 2017, 175, 231-240
15.
Marcotuli I, Hsieh YSY, Lahnstein J, Yap K, Burton RA, Blanco A, Fincher GB, Gadaleta A. Variation in arabinoxylan structure and content in endosperms and brans of durum wheat (Triticum turgidum L.). Journal of Agricultural and Food Chemistry. 2016, 64, 2883-2892
14.
Hsieh, YSY; Zhang Q; Yap K; Shirley N, Lahnstein J.; Nelson CJ; Burton RA; Miller. HA; Bulone V; Fincher GB. Genetics, transcriptional profiles and catalytic properties of UDP-arabinose mutases from barley. Biochemistry 2016, 55, 322-334
13.
Kendall, KR; Hsieh, YSY; Betts, NS; Byrt, CS; Henderson, M; Stork, J; DeBolt, S; Fincher, GB; Burton, RA. Grape marc as a source of carbohydrates for bioethanol: chemical composition, pre-treatment and saccharification. Bioresource Technology. 2015, 193, 76-83
12.
Hsieh, YSY; Wijeyewickrema, LC, Wilkinson, BL, Pike, RN, Payne, RJ. Total synthesis of homogeneous variants of hirudin P6: A post-translationally modified anti-thrombotic leech-derived protein. Angewandte Chemie International Edition. 2014, 126(15): 4028-4032.
Highlighted in Chemistry in Australia
11.
Liao, SF; Liang, CH; Ho, MY; Hsu, TL; Tsai, TI, Hsieh, YSY, Tsai, CM; Li, ST; Cheng, YY; Tsao, SM; Lin, TY; Lin, ZY; Yang, WB; Ren, CT; Lin, KI; Khoo, KH; Lin, CH; Hsu, HY; Wu, CY; Wong, CH. Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes. Proceedings of the National Academy of Science of the United States of America. 2013, 110, (34) 13809-13814
10.
Wong, ACY; Froud, KE; Hsieh YSY. Noise-induced hearing loss in the 21 century: A research and translational update. World Journal of Otorhinolaryngology. 2013, 3, (3) 58-74
Hsieh, YSY; Harris PJ. Structures of xyloglucans in primary cell walls of gymnosperms, monilophytes (ferns sensu lato) and lycophytes. Phytochemistry, 2012, 79, 87-101
9.
8.
Hsieh, YSY; Wilkinson, BL; O’Connell, MR, Mackay, JP, Matthews, JM, Payne, RJ. Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants. Organic Letters, 2012, 14(7): 1910-1913.
Highlighted in the Peptides virtual issue for research published in J. Am. Chem. Soc., Org. Lett. and J. Org. Chem.
Hsieh, YSY; Taleski, D; Wilkinson, BL; Wijeyewickrema, LC; Adam, TE; Pike, RN; Payne, RJ. Effect of O-glycosylation and tyrosine sulfation on leech-derived peptides for binding and inhibitory activity against thrombin. Chemical Communications, 2012, 48, 1547-1549.
Included in the 2012 Emerging Investigators Issue
7.
Thomas, GL; Hsieh, YSY; Chun, CKY; Cai, ZL; Reimers; JR; Payne, RJ. Peptide ligations accelerated by N-terminal aspartate and glutamate residues. Organic Letters, 2011, 13(18), 4770-4773.
6.
Hsieh, YSY; Wong, CY. Composition of polysaccharides in primary walls of Litchi chinesis Sonn. Journal of Food Biochemistry. 2010, 34(5) 971-982.
5.
Hsieh, YSY; Harris, PJ. Structural diversity, function and biosynthesis of xyloglucans in angiosperm cell walls. New Zealand Journal of Forestry Science, 2009, 39, 187-196
4.
3.
Hsieh YSY, Liao SF, Yang WB. Biologically active polysaccharide in medicinal plants. New Zealand Journal of Forestry Science, 2009, 39, 217-223
2.
Hsieh, YSY; Harris, PJ. Xyloglucans of monocotyledons have diverse structures. Molecular Plant. 2009, 2(5) 943-965
Hsieh, YSY; Chien, C; Liao, SKS; Liao, SF; Hung, WT; Yang, WB; Lin, CC; Cheng, R; Chang, CC; Fang, JM; Wong, CH. Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense. Bioorganic & Medicinal Chemistry, 2008, 16(11), 6054-6068.
Patents from this work: Link
1.
Patents
Chi-Huey Wong, Jim-Min Fang, Wen-Bin Yang, Ting-Jen Rachel Cheng, Yves S.Y. Hsieh, Cheng Chien, Chih-Chien Lin, Hao-Yu Wen. Structure and bioactivity of the polysaccharides and oligomers in medicinal plant Dendrobium huoshanense. (Serial Number-378263. U.S. Patent Application filed Feb 22, 2008).
C.-H. Wong, J.-M. Fang, W.-B. Yang, T.-J. R. Cheng, Y. S.Y. Hsieh, C. Chien, C.-C. Lin, H.-Y. Wen, 2009, “Structure and Bioactivity of the Polysaccharides in Medicinal Plant Dendrobium huoshanense”, WO/2009/102880, CT Patent Application, pp. No. PCT/US2009/033940.
C.-H. Wong, J.-M. Fang, W.-B. Yang, T.-J. R. Cheng, Y. S.Y. Hsieh, C. Chien, C.-C. Lin, H.-Y. Wen, 2009, “Structure and Bioactivity of the Polysaccharides in Medicinal Plant Dendrobium huoshanense”, Taiwan Patent Application, pp. No. 098104560.
